Check Closely (two)pentobarbital will decrease the level or impact of suvorexant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Robust CYP3A4 inducers may well lessen suvorexant efficacy; if elevated suvorexant dose required, usually do not exceed twenty mg/working daypentobarbital will lessen the level or outcome